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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: Mol Cancer Res. 2018 Feb 5;16(5):777–790. doi: 10.1158/1541-7786.MCR-17-0413

Fig. 6. Combined AF and temozolomide treatment blocks regrowth in GBM xenografts.

Fig. 6

(A) Bioluminescence data of mice treated with control diet, SPC, TMZ (5 mg/kg, 2 consecutive days) alone, or in combination. (B) TMZ alone or in combination with SPC diet effectively reduced tumor growth at early stages of tumor development. (C–D) Bioluminescence showing regrowth of tumors following TMZ treatment, but not after a combination of TMZ and SPC diet. (E) Kaplan-Meier (n=9 for control, n=8 for SPC, n=9 for TMZ and n=7 for SPC + TMZ, **P < 0.01; Log-rank Mantel-Cox test) curve displays regrowth after ~50 days post-TMZ treatment. Tumors in mice treated with a combination of SPC and TMZ never displayed regrowth.