TABLE 2.
Potency and efficacy of synthetic cannabinoids in agonist-stimulated [35S]GTPγS in HEK293 cell membranes
| Compound | pEC50 | pEC50 | EC50 | EC50 95% CI | Emax | Emax |
|---|---|---|---|---|---|---|
| 95% CI | nM | nM | 95% CI | |||
| hCB1 | ||||||
| CP55,940 | 9.754 | 9.58–9.928 | 0.1762 | 0.118–0.2631 | 59.79 | 55.95–63.63 |
| THC | 8.261 | 7.917–8.605 | 5.479 | 2.482–12.09 | 31.79 | 27.36–36.22 |
| MMB-FUBINACA | 9.265 | 9.024–9.506 | 0.5433 | 0.3118–0.9467 | 69.42 | 62.65–76.19 |
| MDMB-FUBINACA | 9.574 | 9.319–9.829 | 0.2668 | 0.1482–0.48 | 74.77 | 67.68–81.86 |
| MN18 | 8.693 | 8.421–8.965 | 2.028 | 1.085–3.79 | 76.59 | 68.91–84.28 |
| NNEI | 8.023 | 7.684–8.362 | 9.481 | 4.343–20.7 | 69.00 | 58.70–79.30 |
| CUMYL-PICA | 7.921 | 7.677–8.166 | 11.98 | 6.82–21.06 | 75.57 | 67.25–83.89 |
| 5F CUMYL-PICA | 8.234 | 7.874–8.595 | 5.834 | 2.544–13.38 | 70.37 | 59.99–80.76 |
| hCB2 | ||||||
| CP55,940 | 9.842 | 9.571–10.11 | 0.144 | 0.07713–0.2688 | 36.77 | 32.99–40.56 |
| THC | 9.75 | 8.823–10.68 | 0.1777 | 0.02098–1.504 | 12.6 | 8.284–16.91 |
| MMB-FUBINACA | 9.893 | 9.448–10.34 | 0.1278 | 0.04584–0.3566 | 24.48 | 21.01–27.94 |
| MDMB-FUBINACA | 9.851 | 9.502–10.2 | 0.1411 | 0.0632–0.3149 | 35.71 | 31.61–39.80 |
| MN18 | 8.909 | 8.499–9.319 | 1.233 | 0.48–3.169 | 24.02 | 20.40–27.64 |
| NNEI | 8.996 | 8.613–9.379 | 1.008 | 0.4175–2.435 | 20.85 | 17.95–23.76 |
| CUMYL-PICA | 7.791 | 7.501–8.08 | 16.2 | 8.315–31.56 | 29.36 | 25.47–33.25 |
| 5F CUMYL-PICA | 7.854 | 7.557–8.151 | 14 | 7.071–27.73 | 32.84 | 28.41–37.27 |