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. 2018 Apr 26;9:393. doi: 10.3389/fphys.2018.00393

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Copyright © 2018 Chen, Feng, Huo and Tan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic illustration of the 2D model for Ca²⁺ waves. (A) Schematic representative of the 2D geometrical model of a cardiac myocyte. The yellow circles denote JSRs. The spacing intervals between JSRs: l_x = 2 μm and l_y = 0.8 μm. (B) Schematic representative of two JSRs, which include randomly distributed clustered and rogue RyRs (l = 0.1 μm). (C) A flow diagram for the Monte Carlo simulations.