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Interplay of rogue and clustered RyRs in neighbor JSRs. Snapshots of Ca2+ release events in a computational region of 20 × 20 μm2 were taken at 10, 20, and 40 ms from left to right when a CRU of clustered RyRs was fired. (A) Rogue RyRs in a neighbor JSR are activated. (B) Clustered RyRs in a neighbor JSR are initiated by a Ca2+ spark directly. (C) Clustered RyRs are triggered with the help of rogue RyRs.
