Figure 6.

Volcano plots to compare effect of hypoxia on the proteome of WT and Hif1a^−/− MS5 cells. Gene expression fold changes of normoxic vs. hypoxic (A) WT MS5 and (B) Hif1a^−/− MS5 cells are plotted in the x axis vs. Log₁₀ of the p-values derived from a t-test (y axis). Red horizontal dashed lines represents a p-value of 0.05 [–Log (0.05) = ~1.3], while green vertical lines indicate Log₂ fold changes of −1.5 (left) and 1.5 (right). Names of proteins with p < 0.05 and Log₂ fold changes >1.5 are indicated.