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. 2018 Apr 10;9:696. doi: 10.3389/fmicb.2018.00696

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Copyright © 2018 Cha, Oh, Jang, Jo, Kim, Ha, Ko and Myung.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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In vivo efficacy of the phage cocktail containing PBAB08 and PBAB25 in a mice nasal infection model. (A) Survival of 4 groups of mice observed for 7 days after bacterial infection. Group 1 (closed circle) was inoculated with SM buffer only. Group 2 (open circle) was infected with MDR A. baumannii strain 28 only. Group 3 (triangle) was treated with the phage cocktail only. Group 4 (rectangle) was infected with A. baumannii and treated with the phage cocktail. (B) Bacterial load in lungs of infected mice in 3 and 4 days post-infection with or without phage treatment. ^**P < 0.01.