. 2018 May 2;3(3):e00464-17. doi: 10.1128/mSphere.00464-17

TABLE 1 .

Characteristics and reference isolates of lineages of CC8

Traditional strain nomenclature	Known isolate(s) (other names)	Reference(s)	Main SCCmec type(s)	Main spa type(s)	Main sequence type	WGS- based clade
ST239	JKD6008, T0131, TW20	69–71	III	t037, t431, t030	ST239	ST239
ST630	Unknown		V^a	t377^a, t4549^a	ST630	ST630
Archaic	Newman, COL, NCTC 10442	11, 15, 72, 73	I	t051	ST250	CC8a
Iberian	HPV107, PER34, EMRSA5, E2125, NRS209 (28243, NR-46003)	11, 15, 21, 54, 55, 74, 75	I	t051	ST247	CC8a
	NCTC 8325, BR-VRSA	29, 75	II, III, IVa^b	t334	ST8, ST1181	CC8b
USA500/Iberian^c	NRS385 (95938, NR-46071), BAA-1763 (GA229)	21, https://www.atcc.org/Products/All/BAA-1763.aspx	IV	t064	ST8	CC8c
CMRSA9	01S-0965	31, 76	VIII	t008	ST8	CC8d
USA500^c	BD02-25, CA-224 (NRS645, NR-46174)	7, 21	IV	t008	ST8	CC8e
Early Branching USA300	V2200, HUV05	14	IV	t008	ST8	CC8e
USA300-NAE	FPR3757, TCH1516 (USA300-HOU-MR)	77–79	IVa	t008	ST8	CC8f
USA300-SAE	M121, CA12	14	IVc	t008	ST8	CC8e

^{^a}

t377 is based on this study, and SCCmec type V and t4549 are based on one MRSA isolate (44).

^{^b}

Each SCCmec type is based on one MRSA isolate. Most isolates in this clade are MSSA.

^{^c}

We have made the distinction between USA500 and USA500/Iberian, as recent work (including unpublished data from the CDC and data from Albrecht et al. [4]) has characterized new isolates based on the presence of sea and seb genes (7) and SCCmec type IV. See Materials and Methods for details.