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Schematic view of exploiting Tregs for the treatment of SLEIL-2 expands both tTreg/nTreg and pTreg including tissue Treg. Rapamycin and CaMK4 inhibitor facilitate the differentiation of Treg and inhibit TH17. Rapamycin can also stabilize the Treg function. tTreg, thymic regulatory T-cells; nTreg, naïve Treg; pTreg, peripheral Treg; TH17, IL-17-producing helper T-cells.
