Table 1.
Genes and phenotypes of regulatory T cells detected in humans.
| Tissue | Phenotype | Foxp3 | CD45RA | CD25 | CTLA4 | GITR | ICOS | CD127 | Others genes | References |
|---|---|---|---|---|---|---|---|---|---|---|
| Blood | Resting/naive | + | + | + | − | − | − | − | (15) | |
| Activated/memory | ++ | − | ++ | + | + | + | − | T-bet, GATA-3, RORγt, Bcl-6 | (13, 16, 17) | |
| Type 1 T regulatory | − | − | − | n.d. | n.d. | + | − | IL-10, CD49b, LAG3, AhR | (18–20) | |
| Skin | Memory | + | − | ++ | + | + | + | − | IL-17 | (46) |
| Lung | Activated | + | − | + | + | − | + | − | (30) | |
| Colon | Effector | ++ | − | ++ | + | + | n.d. | − | IL-17, RORγt, CD49d, CD103 | (22, 31) |
| Visceral adipose tissue | Activated | + | −/+ | + | n.d. | n.d. | n.d. | − | ST2, OX40 | (25, 32, 34) |
| Joint | Activated | + | − | ++ | n.d. | n.d. | n.d. | − | IL-17, CD161 | (33) |
n.d., not determined.