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Replication cycle of PERV and strategies of PERV detection in xenotransplantation. 1, detection of viral RNA; 2, detection of viral DNA; 3, evaluation of reverse transcriptase activity; 4, detection of PERVs proteins; 5, detection of PERVs antibodies. RT, reverse transcriptase; cross and question mark, PERV-C there is no body of evidence for the possibility of human cells infection in vivo.
