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. 2018 Apr 11;12:100. doi: 10.3389/fncel.2018.00100

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Copyright © 2018 Qiu and Müller.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mechanically gated ion channels in hair cells. (A) Diagram of a hair cell with the sensory channel located at the tips of the shorter stereocilia, reverse-polarity channel in the apical cell surface and stretch-activated channels in the basolateral membrane. (B) The sensory transduction channel is localized near the lower end of tip links, which consists of PCDH15 and CDH23. (C) The reverse-polarity channel is concentrated near the base of the longest stereocilia. (D) Basolateral currents carried by unknown channels. Cl⁻ influx through basolateral channel may drive motor protein prestin transitions.