Table 1.

Candidate components of the mechanotransduction channel in hair cells and how they affect channel activity.

Candidates	Stereocillia localization	MET requirement	Channel properties changed in mutant mice				Heterologous expression
			Rise time	Adaptation	Single-channel conductance	Calcium permeability
TMC1/2	Yes	Required	N/A	Slower	Conflict	Altered	Intracellular
LHFPL5	Yes	Required	Slower	Slower	Reduced	N/D	Cell surface together with Pcdh15
TMIE	Yes	Required	N/A	N/A	N/A	N/A	Cell surface