Figure 2.
Crystal structure of hemaglutinin (HA) sialic acid residue binding site of H1N1pdm09, H5N1, and airborne-transmissible H5N1. The sialic acid residue binding site on the HA of (A) A/Washington/5/2011 (H1N1pdm09; PDB: 4LKX), (B) A/Vietnam/1203/2004 (H5N1; PDB: 2FK0), and (C) H5N1 with Asn148Asp, Gln222Leu Asn224Lys Gln226Leu, and Gly228Ser. These amino acid residues were changed in silico and modeled using HA of H5N1(PDB: 2FK0) as a template in SWISS-MODEL. Protein visualization and distance calculation was performed in UCSF Chimera molecular visualization application.