Figure 2.

Structural organization of glomeruli and tubules of kidneys from mice of control plus vehicle (0.9% NaCl, 1 ml/kg/day i.p.), control plus flavocoxid (20 mg/kg/day i.p.), CdCl₂ (2 mg/kg/day i.p.) plus vehicle, and CdCl₂ plus flavocoxid groups (hematoxylin and eosin stain). (a, b) In both control groups, glomeruli and tubules show normal architecture. (c) In CdCl₂-challenged mice, glomeruli present enlarged Bowman's space (arrow), while tubules show epithelial lesions (arrowhead). A mild interstitial edema is also present (∗). (d) In CdCl₂-challenged mice administered with flavocoxid, glomerular and tubular morphology is normal. (e) Glomerular area evaluation. ^∗p < 0.05 versus both controls and ^†p < 0.05 versus CdCl₂ plus vehicle (scale bar: 50 μm).