. 2015 Jun 3;1(1):69–86. doi: 10.3390/ncrna1010069

Table 1.

Published GSC profiling studies as well as the dysregulated lncRNAs identified.

Authors ¹	Year	Samples	No. of	No. of	Ref.
Authors ¹	Year	Samples	Up-regulated LncRNAs (≥2.0 fold) ²	Down-regulated LncRNAs (≥2.0 fold) ²	Ref.
Dysregulated LncRNAs between GSCs and Differentiated GBM Cells Comparison
Araki et al.	2013	GSC (sphere) vs. differentiated GBM cells	6: LOC100127888, H19, RP11-112J3.16, et al.	28: DLX6-AS, LOC643763, FLJ39609, et al.	[47]
Aldaz et al.	2013	GSC (sphere) vs. differentiated GBM cells	28: H19, MIAT, LOC150622, LOC100127888, XIST, RP11-112J3.16, et al.	11: RP11-346D6.6, C6orf155, HCG4, FLJ39609, et al.	[42]
Dysregulated LncRNAs between GSCs with Different Subtypes
Beier et al.	2007	CD133 + GSCs vs. CD133 − GSCs	38: XIST, H19, HOTAIR, LOC100192378, AC006213.1, MIAT, et al.	34: CTC-231O11.1, RP11-745C15.2, LOC100130776, C14orf139, et al.	[40]
Gunther et al.	2008	CD133+ GSCs vs. CD133 − GSCs	51: H19, RP11-331K15.1, RP11-547I7.2, LOC100192378, MIAT, HOTAIR, et al.	10: C14orf139, DLX6-AS, MIR155HG, LOC100130776, et al.	[41]
Dysregulated LncRNAs between GSCs and NSCs Comparison
Rheinbay, et al.	2013	GSCs vs. NSCs	173: LOC399959, LOC645323, HOTAIRM1, H19, MALAT1, SOX2ot, et al.	19: HYMAI, AL133167.1, FLJ31485, et al.	[58]

¹ Profiling studies searching was performed in public GEO database (December, 2014). Only the datasets profiled on Affymetrix HG-U133 Plus 2.0 microarray platform were enrolled in our review analysis. With regard to how to process Affymetrix HG-U133 Plus 2.0 raw data and mine lncRNA information from it, please refer to our previous paper for details [43]. ² For each individual study reviewed here, the total number of dysregulated lncRNAs, as well as the representative candidates were listed. Representative candidates were defined if they fulfilled one of following the criteria: (1) They were the top 3 dysregulated genes in comparison; (2) They appeared in more than one independent study reviewed at the same dysregulation pattern; (3) They have been functionally reported in public studies, especially in cancer.