Figure 3.

Endurance exercise is detrimental for HD. (A) Immunoblots for AMPKα activation in TA muscles (n = 4 in WT, n = 6 in HD groups) after 6 weeks of sedentary or exercise (B) Whole body fat and lean mass in male WT (n = 5) and HD (n = 7) mice before (around 7–8 weeks of age) and after 6 weeks sedentary or exercise regime. (C) Graph showing decrease survival in HD mice with endurance exercise (n = 7; P = 0.003). (D) TEM images from TA muscles of HD mice in the sedentary and exercise group (yellow arrow pointed at mitochondria). Quantification of the average mitochondria total area in TEM. Each bar represents the average of n = 2–4 mice per group in at least three comparable micrographs per mouse including 40–60 mitochondria per micrograph. Graph bars represent mean ± SEM. Statistical evaluation between HD groups by two-tailed t-Student with Welch’s correction. *P < 0.05, **P < 0.01.