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. 2018 Mar 16;27(10):1830–1846. doi: 10.1093/hmg/ddy093

Figure 3.

Figure 3.

SLC1A4 is associated with multiple clinical traits. (A) Manhattan plot showing EWAS results for insulin resistance index HOMAIR. Each dot is a CpG region, the genomic location of each CpG region is on the x-axis with chromosomes shown in alternating colors, the association significance is on the y-axis, significant hits are shown as red dots. (B) Association results for multiple phenotypes near the SLC1A4 locus. Each dot represents a different association to a CpG region, different colored points represent distinct clinical traits, the genomic location of each CpG region is on the x-axis, the association significance is on the y-axis. Red vertical bars denote the transcription start and end of SLC1A4. The dotted significance threshold line is drawn at 5 × 10−8. (C) cis-eQTL results for SLC1A4 expression in adipose tissue biopsies. Each dot represents a SNP, the genomic location of each SNP is on the x-axis, the association significance is on the y-axis, significant SNPs are shown as red dots. Red vertical bars denote the transcription start and end of SLC1A4. The dotted significance threshold line is drawn at 5 × 10−8. (D–F) Each point represents an individual in the cohort, showing correlation between (D) methylation levels for the peak associated CpG region and HOMAIR, (E) methylation levels for the peak CpG region and expression of SLC1A4 and (F) expression of SLC1A4 and HOMAIR.