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. 2018 Mar 13;39(5):708–718. doi: 10.1093/carcin/bgy040

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© The Author(s) 2018. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 1. — Landscape of genomic aberrations in syCRCs. Each column represents a tumour; contiguous tumours are syCRCs from one patient. The top panel shows the number of somatic mutations. Group 1 comprised patients in whom both syCRCs are hypermutated. Group 2 comprised patients in whom one tumour is hypermutated, but the other is non-hypermutated. Group 3 comprised patients in whom both syCRCs are non-hypermutated. The next panel presents patients’ information including tumour location, stage, gender and mutation status (Mut status). The middle panel presents the frequently mutated genes in our cohort study, and the frequency is shown on the right. Germline mutations of common CRC-related hereditary genes are also shown (specific mutations are on the right). The bottom panel indicates the somatic copy number aberrations.