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. 2018 Apr 26;9:874. doi: 10.3389/fimmu.2018.00874

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Copyright © 2018 Mayeux, Escalante, Christy, Pawar, Kono and Pollard.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sex differences in silica-exposed diversity outbred mice. Mice were exposed transorally to crystalline silica in PBS (see Figure 1) and females and males analyzed separately for sex effects by two-way ANOVA using Sidak’s multiple comparisons. Males exposed to 10 mg were found to have higher (A) alveolitis, (B) bronchoalveolar lavage fluid (BALF) cell number, (C) BALF IL-6, and (D) ENA5 autoantibodies compared to females at the same dose.