Table 6.

Western blot analysis of MMP and tight junction protein expression levels in brain capillaries isolated from rats after SE that were treated with or without the cPLA₂ inhibitor ATK (Fig. 7A)^a

Protein	Control	Pilo	SE	SE + ATK
MMP-2	100 ± 2.9	102.6 ± 2.9	145.2 ± 3.4*	111.3 ± 2.8
MMP-9	100 ± 3.9	106.2 ± 3.5	139.6 ± 9.2*	99.2 ± 4.3
ZO-1	100 ± 11.6	115.7 ± 16.4	53.4 ± 8.4*	101.8 ± 15.7
Occludin	100 ± 16.9	96.1 ± 19.1	41.2 ± 5*	89 ± 23.6
Claudin-1	100 ± 15.3	95.3 ± 16.6	49 ± 3.7*	105.5 ± 18.4
Claudin-5	100 ± 15.6	92.4 ± 17.1	44.9 ± 3.8*	110.7 ± 19

^aData were normalized to β-actin levels; values are percentage control ± SD (n = 3).

*p < 0.05, each endpoint versus control (Dunnett's many-to-one t test).