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MSCs significantly inhibited MMP-9 upregulation in protein level and activity at days 1 and 3 following transient MCAO. a Western blot analysis of MMP-9. Treatment with MSCs downregulated the levels of MMP-9 1 and 3 days after tMCAO when compared with the PBS group. n = 4–6 in each time point per group. b Zymography and quantification of active MMP-9 levels in mice brain from four groups at 1 and 3 days after tMCAO. Data are mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001
