Fig. 4.

Time schedule of enrolment, interventions and assessments. Abbreviations: BMI Body mass index, BP Blood pressure, DXA Dual-energy X-ray absorptiometry, ECG Electrocardiogram, MRI Magnetic resonance imaging, HC Hip circumference, VO₂ max Maximal oxygen consumption rate, WC Waist circumference, MMTT Mixed-meal tolerance test, OGTT Oral glucose tolerance test, RM Repetition maximum. ¹Eligibility screen was conducted in a telephone interview before study day 1. ²The exercise intervention is a 12-week supervised exercise programme with three sessions per week consisting of either endurance or resistance exercise training. ³Blood samples will be drawn after an overnight fast (> 10 hours) and analysed for haematologic, renal, endocrine, cardiac and hepatologic markers. Table is adapted from the SPIRIT recommendations [38]