Table 3.
Secondary outcomes
| Secondary outcomes | Intervention group (DOT + SMS) n = 137 |
Control group (DOT) n = 142 |
Effect Estimate |
|---|---|---|---|
| n (%) | n (%) | OR [95% CI]; p | |
| At 2 months | |||
| Attendance to appointments | |||
| Number of patients followed | 125 (91.2) | 124 (87.3) | 1.51 [0.69, 3.27]; 0.29 |
| Number of patients withdrawn | 12 (8.7) | 18 (12.7) | 0.66 [0.30, 1.43]; 0.29 |
| Transferred out | 2 (1.5) | 6 (4.2) | 0.33 [0.06, 1.69]; 0.16 |
| Deceased | 1 (0.7) | 3 (2.1) | 0.34 [0.03, 3.31]; 0.33 |
| Lost to follow-up | 9 (6.6) | 9 (6.4) | 1.03 [0.39, 2.70]; 0.93 |
| Punctuality to appointment dates | |||
| Early and Prompt | 98 (71.5) | 104 (73.2) | 0.91 [0.54, 1.55]; 0.74 |
| Late | 27 (19.7) | 21 (14.8) | 1.41 [0.75, 2.64]; 0.27 |
| Mean (SD) / (Min, Max) |
Mean (SD) / (Min, Max) | MD [95% CI]; p | |
| Adherence to prescription drugs (%, VAS) | 98.5 (6.3) / (50, 100) |
99.3 (3.5) / (70, 100) |
- 0.8 [−2.0, 0.5]; 0.25 |
| At 5 months | |||
| Attendance to appointments | |||
| Number of patients followed | 112 (81.7) | 108 (76.0) | 1.41 [0.78, 2.51]; 0.24 |
| Number of patients withdrawn | 25 (18.3) | 34 (24.0) | 0.70 [0.39, 1.26]; 0.24 |
| Transferred out | 5 (3.7) | 6 (4.2) | 0.85 [0.25, 2.88]; 0.80 |
| Deceased | 1 (0.7) | 4 (2.8) | 0.25 [0.02, 2.29]; 0.18 |
| Lost to follow-up | 19 (13.9) | 24 (17.0) | 0.79 [0.41, 1.52]; 0.48 |
| Punctuality to appointment dates | |||
| Early and Prompt | 69 (50.4) | 70 (49.3) | 1.04 [0.65, 1.66]; 0.85 |
| Late | 44 (32.1) | 38 (26.8) | 1.29 [0.77, 2.17]; 0.32 |
| Mean (SD) / (Min, Max) |
|||
| Adherence to prescription drugs (%, VAS) | 98.9 (5.8) / (50, 100) |
99.2 (3.8) / (70, 100) |
- 0.3 [−1.5, 1.1]; 0.73 |
| At 6 monthss | |||
| Attendance to appointments | |||
| Number of patients followed | 88 (64.2) | 90 (63.4) | 1.03 [0.63, 1.69];0.88 |
| Number of patients withdrawn | 49 (35,8) | 52 (36.6) | 0.96 [0.59, 1.57]; 0.88 |
| Transferred out | 5 (3.6) | 6 (4.2) | 0.85 [0.25, 2.88]; 0.80 |
| Deceased | 2 (1.5) | 6 (4.2) | 0.33 [0.06, 1.69]; 0.16 |
| Lost to follow-up | 42 (30.7) | 40 (28.2) | 1.12 [0.67, 1.88]; 0.64 |
| Punctuality to appointment dates | |||
| Early and Prompt | 65 (47.4) | 69 (48,6) | 0.95 [0.59, 1.52]; 0.84 |
| Late | 23 (16.8) | 21 (14.8) | 1.16 [0.61, 2.21]; 0.64 |
| Mean (SD) / (Min, Max) | Mean (SD) / (Min, Max) | MD [95% CI]; p | |
| Adherence to prescription drugs (%, VAS) | 99.7 (1.8) / (80, 100) |
99.5 (1.7) / (90, 100) |
0.2 [−0.4, 0.7]; 0.53 |
DOT directly observed treatment, SMS short message service, OR odds ratio, CI confidence interval, Early at least 5 days before, Normal between 4 days before and 4 days after, Late starting from 5 days after, SD standard deviation, MD mean difference, VAS visual analog scale