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. 2018 May 2;11:25. doi: 10.1186/s13041-018-0367-6

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Treg enhance OPC differentiation and reduce neuronal percentages in mixed neuron-glia cultures. Mixed neuron-glia cultures were treated with 5% Treg-conditioned media or matched medium control for 5 days. Immunofluorescence analysis (a) of Olig2⁺ oligodendroglial cell population for percentage of OPCs (PDGFRα⁺), oligodendrocytes (MBP⁺) and proliferating OPCs (Ki67⁺) and (b) of DAPI⁺ cells for percentage of oligodendroglial lineage cells (Olig2⁺), neurons (MAP2⁺) and microglia (CD11b⁺), n = 6 wells, mean +/− SEM, Mann-Whitney test, (*) p < 0.05, (**) p < 0.01, representative of two independent experiments. Data are from 5 different experiments depending on timepoint and marker. FOV = field of view = 1 mm²