Table 5.
Summary of neuropsychological testing data with NIH Toolbox for Cognition (score and SD)
| NIH Toolbox score | Time point 1 | Time point 2 | Change over time | ||||
|---|---|---|---|---|---|---|---|
| Chemotherapy group | Healthy controls | Chemotherapy group | Healthy controls | Chemotherapy group | Healthy controls | p** | |
| Crystallized composite | 110.87 (16.12) | 107.38 (15.57) | 110.56 (11.82) | 107.05 (18.53) | − 0.31 (7.21) | − 0.33 (6.44) | 1.00 |
| Fluid composite | 99.69 (14.43) | 99.22 (10.65) | 100.23 (14.62) | 105.08 (15.85) | 0.54 (11.66) | 5.86 (11.84) | 0.23 |
| Total composite | 105.10 (19.11) | 101.48 (15.02) | 104.14 (15.05) | 105.11 (20.37) | − 0.95 (10.00) | 3.63 (8.78) | 0.20 |
| Dimensional change card sort | 100.66 (11.83) | 101.78 (12.62) | 101.70 (7.06) | 106.91 (9.64) | 1.04 (8.37) | 5.13 (12.26) | 0.29 |
| Flanker Inhibitory control | 95.78 (10.97) | 96.92 (9.12) | 92.50 (9.25) | 99.74 (6.11) | − 3.27 (12.33) | 2.81 (6.77) | 0.11 |
| Working memory | 101.45 (16.31) | 100.18 (16.35) | 107.01 (10.64) | 105.00 (17.00) | 5.57 (10.19) | 4.83 (14.10) | 0.87 |
| Oral reading recognition | 111.52 (11.95) | 103.37 (12.51) | 107.80 (12.33) | 103.45 (14.00) | −3.71 (5.74)* | 0.09 (6.91) | 0.11 |
| Processing speed | 91.29 (14.08) | 96.84 (14.06) | 91.14 (17.05) | 95.39 (16.45) | − 0.14 (14.94) | − 1.44 (14.94) | 0.81 |
| Episodic memory | 111.73 (20.06) | 103.49 (15.26) | 109.70 (21.33) | 110.29 (25.05) | −2.02 (12.24) | 6.80 (21.18) | 0.17 |
| Picture vocabulary | 107.06 (14.94) | 109.13 (16.63) | 110.30 (8.88) | 107.66 (16.52) | 3.23 (9.94) | − 1.47 (6.30) | 0.14 |
*p = 0.02
**p comparing change over time between chemotherapy group and healthy control group. Bold numbers indicate key findings