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DUOX1 silencing blunts IL-6 and IL-8 mRNA levels and secretion increase after genotoxic stress. DUOX1-deficient (shDUOX1) and control (shCTRL) cells were treated or not with 25 nM doxorubicin for 48 h. IL-6 (a) and IL-8 (b) mRNA levels were evaluated by quantitative RT-PCR; IL-6 (c) and IL-8 (d) secretion was measured by flow cytometry utilizing the CBA assay. Results are expressed as mean ± SEM of three independent experiments. ∗∗∗P < 0.001.
