Table 2.
Allele and genotype frequency of two genetic variants in LUZP2 and FBXO40 genes in the total sample and in the lower (Q1) and upper (Q4) quartiles of the MoCA distribution.
| Allele, haplotype | Total sample, N = 708 | Lower quartile (MoCA < 20), N = 152 | Upper quartile (MoCA > 25), N = 132 | Q1 versus Q4, p |
|---|---|---|---|---|
| LUZP2 rs1021261 | ||||
| G | 0.691 | 0.635 | 0.667 | 0.480 |
| T | 0.309 | 0.365 | 0.333 | |
| GG | 0.383 | 0.428 | 0.409 | 0.809 |
| GT | 0.480 | 0.414 | 0.515 | 0.096 |
| TT | 0.137 | 0.158 | 0.076 | 0.043 |
|
| ||||
| FBXO40 rs3772130 | ||||
| A | 0.745 | 0.799 | 0.720 | 0.029 |
| G | 0.255 | 0.201 | 0.280 | |
| AA | 0.572 | 0.671 | 0.523 | 0.014 |
| AG | 0.347 | 0.257 | 0.394 | 0.015 |
| GG | 0.081 | 0.072 | 0.083 | 0.825 |