Effect of stress on nociception. A, There was a decrease in latency of paw withdrawal from before surgery to after surgery/before stress in the sham-no stress group and from before surgery to after stress in the endo-stress group (%
P < .05 vs before surgery). B, Endo-no stress and sham-no stress groups decreased their tolerance to mechanical testing from their first exposure (%
P < .05, %%
P < .01, %%%
P < .001 vs day 1). C, Sham-no stress and endo-stress groups demonstrated a decrease in sensitivity after surgery (%%
P < .01 vs day 1), but only the endo-stress group recovered from the allodynic effect after the stress protocol (%%%
P < .001 vs day 1; n = 12 ± standard error of the mean [SEM]).