Figure 2.

Gene expression in neuronal regulation pathways. A, Gene ontology analysis and ingenuity pathway analysis (IPA) results of messenger RNA (mRNA) microarray data identified gene expression changes in several pathways that could impact neuronal development: neuronal differentiation, neuronal morphogenesis, regulation of neuron cell death, and neuronal migration. B, Of these genes, 6 had significantly decreased gene expression greater than 1.5-fold: Colec12, Dcn, Rarb, Gpc3, Igf2, and Bmp6 and confirmed significance (P < .05) on real-time quantitative polymerase chain reaction (RT-qPCR) validation studies.