Table 1.
Regulatory Programs Associated With Differential Gene Expression in Endometriosis.a
| TF | Cell Type | #Targets | Differential Genes | Upregulated Genes | Downregulated Genes | |||
|---|---|---|---|---|---|---|---|---|
| Number | P Value | Number | P Value | Number | P Value | |||
| AR | PC3 | 2941 | 373 | 2.2E-15 | 146 | 5.6E-06 | 227 | 2.5E-09 |
| CDX2 | CACO-2 | 389 | 54 | 0.00067 | 13 | .69 | 41 | 7.1E-05 |
| CTNNB1 | HCT116 | 897 | 112 | 8.2E-05 | 37 | .21 | 75 | .00014 |
| E2F4 | JURKAT | 697 | 95 | 1.3E-05 | 7 | 1 | 88 | 2.7E-13 |
| EOMES | HESC | 865 | 113 | 1.3E-05 | 45 | .0084 | 68 | .0015 |
| ERG | JURKAT | 294 | 43 | .00089 | 19 | .017 | 24 | .041 |
| ESR1 | MCF7 | 216 | 37 | .00011 | 11 | .21 | 26 | .00025 |
| ESR1 | T-47D | 176 | 31 | .00025 | 12 | .046 | 19 | .0065 |
| ESR2 | MCF7 | 396 | 71 | 1.1E-08 | 25 | .0084 | 46 | 2.7E-06 |
| EWS-FLI1 | SK-N-MC | 517 | 77 | 4.8E-06 | 38 | 4.4E-05 | 39 | .027 |
| FOXA2 | HepG2 | 2823 | 355 | 2.9E-14 | 139 | 1.5E-05 | 216 | 1.4E-08 |
| HNF4A | HepG2 | 5778 | 602 | 9.8E-09 | 232 | .0026 | 370 | 5.6E-06 |
| MITF | Melanoma | 5067 | 533 | 3.3E-08 | 211 | .00078 | 322 | 6.7E-05 |
| MYC | AK7 | 1783 | 195 | .00033 | 80 | .014 | 115 | .020 |
| MYC | Medulloblastoma | 1162 | 162 | 1.9E-09 | 70 | 1.5E-05 | 92 | .00014 |
| MYCN | Shep-21N | 287 | 46 | 8.2E-05 | 8 | .92 | 38 | 1.2E-06 |
| NANOG | HESC | 1152 | 141 | 2.3E-05 | 45 | .26 | 96 | 1.5E-05 |
| PAX3-FKHR | Rhabdomyosarcoma | 969 | 135 | 4.0E-08 | 61 | 1.6E-05 | 74 | .0019 |
| POU3F2 | 501MEL | 1310 | 157 | 2.3E-05 | 63 | .0084 | 94 | .0026 |
| POU5F1 | HESC | 468 | 77 | 9.2E-08 | 26 | .027 | 51 | 4.0E-06 |
| PPARD | Myofibroblast | 3038 | 324 | 1.8E-05 | 137 | .00072 | 187 | .015 |
| SCL | HPC-7 | 207 | 36 | .00010 | 16 | .0084 | 20 | .015 |
| SMAD2 | HaCaT | 1698 | 204 | 8.9E-07 | 73 | .045 | 131 | 1.4E-05 |
| SMAD3 | HaCaT | 1698 | 204 | 8.9E-07 | 73 | .045 | 131 | 1.4E-05 |
| SOX2 | HESC | 878 | 109 | .00012 | 37 | .19 | 72 | .00032 |
| SOX2 | LN229-GBM | 2824 | 356 | 2.4E-14 | 147 | 5.1E-07 | 209 | 3.7E-07 |
| SOX2 | SW620 | 2104 | 350 | 8.8E-36 | 126 | 3.0E-09 | 224 | 5.4E-25 |
| TFAP2C | MCF7 | 1115 | 159 | 5.9E-10 | 50 | .059 | 109 | 2.3E-09 |
| TP53 | U2OS | 728 | 111 | 9.8E-09 | 53 | 2.4E-06 | 58 | .0026 |
| TRIM28 | NTERA2 | 677 | 86 | .00033 | 44 | .00016 | 42 | .20 |
Abbreviations: TF, Transcription Factor; CDX2, Caudal-type homeobox transcription factor 2; CTNNB1, Catenin beta-1; E2F4, E2F transcription factor 4; EOMES, Eomesodermin; ERG, ETS-related gene; EWS-FLI1, Ewings sarcoma/Friend leukemia integration factor; FOXA2, Forkhead box A2; HNF4A, Hepatocyte nuclear factor 4-alpha; MITF, Microphthalmia-associated transcription factor; MYC, c-Myc; MYCN, v-Myc; NANOG, Nanog; PAX3-FKHR, Paired box3 forkhead box; POU3F2, POU class 3 homeobox 2; POU5F1, POU class 5 homeobox 1; PPARD, Peroxisome proliferator-activated receptor delta; SCL, Stem cell leukemia; SMAD2, Mothers against decapentaplegic homolog 2; SMAD3, Mothers against decapentaplegic homolog 3; SOX2, SRY (sex determining region Y) box 2; TFAP2C, Transcription factor AP2 (activating enhancer binding protein 2); TP53, Tumor protein p53; TRIM28, Tripartite Motif containing 28; AR, androgen receptor; ESR1, estrogen receptor α; ESR2, estrogen receptor β.
aTFs are identified if their target genes are significantly enriched in upregulated or downregulated genes in endometriosis versus normal endometrium.