Figure 2.

Pregnyl human chorionic gonadotropin (hCG) causes a decrease in MUC16 messenger RNA (mRNA) while Sigma hCG alone has no effect. There is a negative correlation between Pregnyl hCG concentration and MUC16 mRNA between 5 and 300 IU hCG (A). Sigma hCG does not affect MUC16 mRNA unless supplemented with interleukin 1B which results in a decrease in MUC16 concentration at 750 IU (B, C). Results are represented as fold change from nontreated control Sw.71 cells and represent 3 independent experiments.