Vascular reactivity to Ang II in omental arteries obtained from women with preeclampsia. The vasoconstrictive response to Ang II was significantly enhanced in preeclamptic omental arteries (n = 5) as compared with normal pregnant arteries (n = 11; panel A). The enhanced response of preeclamptic arteries was abolished by removal of the endothelium (n = 2, panel A) or coperfusion with inhibitors of PAR-1 (n = 5), ROCK (n = 5), or ET-1 (n = 4; panel B). a
P < .05, b
P < .01, c
P < .001, d
P < .0001 compared to other treatments for that dose. Ang II indicates angiotensin II; ET-1, endothelin 1; NS, nonsignificant for treatment effects; PAR, protease-activated receptor; ROCK, RhoA kinase.