Figure 5.

Bentamapimod at both 30 mg/kg twice daily (BID) and 60 mg/kg BID causes regression of surgically induced autologous endometriotic-like foci in rats. Uterine segments from each rat were used to establish lesions. Three weeks later, animals with confirmed endometriotic foci were assigned to treatment groups. A sham-treated group received autologous uterine segment removal and adipose transplant near the uterus; they did not develop lesions (not shown). Bentamapimod (AS-01; orally) was administered BID for 9 days, and Antide (subcutaneous injection) was delivered as a single injection. Data are mean ± standard error of the mean (SEM), **P < .05, ***P < .01, analysis of variance (ANOVA) followed by Tukey test.