Table 1.
Molecular Profile of EEC Overexpressing LOX in Human Fibrosis and EMT Super Arrays.
| Human Fibrosisb and EMTc LOX Overexpression Upregulation (>2-fold) | Human Fibrosisb and EMTc LOX Overexpression Downregulation (<.05-fold) | ||||
|---|---|---|---|---|---|
| Gene | Fold Change | P value | Gene | Fold Change | P value |
| LOX b | 173.6278 | .106482 | ACTA2 b | 0.2982 | .001396 |
| RGS2 c | 4.1524 | .001894 | AHNAK c | 0.3857 | .003407 |
| CCL11 b | 0.3925 | .020233 | |||
| CDH1 c | 0.6893 | .057056 | |||
| CDH2 c | 0.86 | .538845 | |||
| FASLG b | 0.4149 | .03351 | |||
| GSK3B c | 0.5418 | .009628 | |||
| IL10 b | 0.1019 | .012177 | |||
| NOTCH1 c | 0.4833 | .009478 | |||
| SMAD6 b | 0.4804 | .041835 | |||
| SNAI1 c | 0.7271 | .279479 | |||
| SNAI2 c | 0.4034 | .071564 | |||
| SNAI3 c | 0.5675 | .067249 | |||
| TGFBR1 b | 0.4284 | .000328 | |||
| TIMP3 b | 0.3954 | .00697 | |||
| VPS13A c | 0.4785 | .017679 | |||
Abbreviations: HF, Human Fibrosis; EMT, Epithelial to Mesenchymal Transition; EEC, endometrial epithelial cell; LOX, lysyl oxidase; RGS2, regulator of G-protein signaling; ACTA, actin, α 2, smooth muscle, and aorta; AHNAK, CCL11, chemokine [C-C motif] ligand 11; FASLG, Fas ligand; GSK3B, glycogen synthase kinase 3 beta; IL10, interleukin 10; NOTCH1, Notch homolog 1, translocation-associated; SNA1, SNA2, SNA3, SNAIL homolog 1-3; TGFBR1, transforming growth factor beta receptor 1; TIMP3, tissue inhibitor metalloproteinase 3; VPS13A, vacuolar protein sorting 13 homolog A.
aSignificant results are shown in bold.
bHF Array (SABiosciences, QIAGEN, Frederick, Maryland).
cEpithelial to Mesenchymal Transition RT2 Profiler Arrays (SABiosciences, QIAGEN, Frederick, MD).