Table 1.
Inhibitory effect of the dimeric adamantane compounds on p7 protein in GTs 1a, 1b, 2a, 3a, and 4ac
| Compound | IC50 (nM) ± SEM*
|
||||
|---|---|---|---|---|---|
| GT1a | GT1b | GT2a | GT3a | GT4a | |
| Amantadine | 0.7±0.4 (5) | 0.6±0.1 (6) | >1,000 (5) | >100 (4) | 3.2±1.2 (5) |
| Rimantadine | 0.7±0.1 (5) | 1.7±1.2 (8) | 24±4 (5) | 1.6±0.6 (5) | 3.0±0.8 (4) |
| 2a | 0.4±0.1 (5) | 1.2±0.2 (3) | 2.8±0.3 (4) | 2.0±0.4 (4) | 1.2±0.2 (4) |
| 2b | 0.4±0.1 (4) | 0.5±0.4 (3) | 0.9±0.1 (3) | 0.9±0.3 (4) | 0.4±0.1 (5) |
| 2c | 1.0±0.2 (7) | 0.7±0.2 (4) | 0.8±0.1 (6) | 0.6±0.1 (9) | 0.8±0.1 (7) |
| 2d | 0.9±0.1 (3) | 1.0±0.3 (4) | 0.6±0.1 (4) | 0.6±0.1 (4) | 0.9±0.2 (4) |
| 2e | 0.6±0.1 (4) | 1.1±0.2 (4) | 0.4±0.1 (3) | 0.6±0.1 (5) | 0.4±0.1 (6) |
| 4a | NA | 1.1±0.3 (3) | NA | NA | 0.7±0.2 (4) |
| 4b | NA | 0.6±0.2 (4) | NA | NA | 2.0±0.1 (3) |
| 4c | NA | 1.1±0.1 (3) | NA | NA | 0.5±0.1 (4) |
| 4d | 0.8±0.2 (3) | 2.3±0.2 (4) | NA | NA | 1.1±0.1 (4) |
| 4e | NA | 1.0±0.3 (7) | NA | NA | 0.8±0.3 (6) |
| 1c | 1.2±0.3 (4) | 0.5±0.1 (4) | >100 (4) | 1.0±0.1 (4) | 0.8±0.1 (4) |
| 5a | 1.3±0.2 (4) | 1.0±0.2 (6) | NA | NA | 0.9±0.1 (4) |
Note:
*
Numbers in parentheses indicate the number of cells used for measurements.
Abbreviations: GT, genotype; NA, not applicable.