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. 2017 Oct 2;125(10):107001. doi: 10.1289/EHP1612

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EHP is an open-access journal published with support from the National Institute of Environmental Health Sciences, National Institutes of Health. All content is public domain unless otherwise noted.

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Nine plots with confidence intervals showing log base 2 PFAS concentrations, namely, PFNA, PFOA, PFHxS, Me-PFOSA-AcOH, PFOS, and Et-PFOSA-AcOH (y-axis) across the change per year (x-axis) for the following glycemic outcomes: HOMA-IR, HOMA-beta, fasting insulin (micro units per milliliter), fasting glucose in milligrams per deciliter, HbA1c in percentage, fasting proinsulin in picomolar, corrected insulin response, insulinogenic index, adiponectin in micrograms per milliliter. — Adjusted estimated change in glycemic outcomes per year for each doubling in per- and polyfluoroalkyl substances (PFAS) plasma concentrations measured at baseline in the Diabetes Prevention Program. Note: Longitudinal models adjusted for participant sex, race/ethnicity, baseline body mass index (BMI) (continuous), age (categorical), marital status (categorical), education (categorical), smoking history (categorical), time to follow-up in years, and treatment assignment (placebo/lifestyle). Et-PFOSA-AcOH, N-ethyl-perfluorooctane sulfonamido acetic acid; Me-PFOSA-AcOH, N-methyl-perfluorooctane sulfonamido acetic acid; PFHxS, perfluorohexane sulfonic acid; PFNA, perfluorononanoic acid; PFOA, perfluorooctanoic acid; PFOS, perfluorooctanesulfonic acid.