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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: J Org Chem. 2017 Aug 14;82(17):9023–9029. doi: 10.1021/acs.joc.7b01467

Table 2.

Dehydrochlorination Optimization

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entry solvent 2nd base assay yield
1 CH2Cl2 TEA 50%
2 CH2Cl2 pyridine 57%
3 CH2Cl2 2,4,6-collidine 84%
4 CH2Cl2 2,6-lutidine 80%
5 CH2Cl2 Hünig base 58%
6 CH2Cl2 N-methyl morpholine 72%
7 CH2Cl2 dimethylaniline 69%
8 MeCN 2,4,6-collidine 97%
9 MTBE 2,4,6-collidine 87%
10 THF 2,4,6-collidine 92%
11 IPAC 2,4,6-collidine 50%
12 2-MeTHF 2,4,6-collidine 75%