Table 1.
Histomorphology | MCN with abundant ovarian-type stroma (confirmed by positive ER/PR) with extensive high-grade dysplasia. |
Microscopic foci of invasive adenocarcinoma budding off the main epithelial lining. | |
Multiple hypercellular areas, comprising markedly atypical cells without glandular differentiation. | |
Atypical cells appear spindled or rhabdoid with eccentrically placed nuclei and dense purple cytoplasm. | |
Immunohistochemistry | SMA, desmin, myogenin, CD10, and INI1 are negative in the hypercellular areas, arguing against a diagnosis of sarcoma. |
Pancytokeratin and CK 7 are strongly and diffusely positive in the hypercellular areas, including the spindled and rhabdoid-appearing cells. EMA is weakly positive in the same population of cells. This staining pattern is most consistent with undifferentiated carcinoma (anaplastic carcinoma). |
CK, cytokeratin; EMA, epithelial membrane antigen; ER, estrogen receptor; MCN, mucinous cystic neoplasm; PR, progesterone receptor; SMA, smooth muscle actin.