Table 3.
Univariate and multivariate predictors of mortality determined by Cox proportional hazards analysis.
| Variables | HR (95% CI) | p-value |
|---|---|---|
| Univariate analysis | ||
| PMX-DHP therapy | 0.485 (0.260–0.904) | 0.023 |
| Age | 1.017 (0.988–1.046) | 0.255 |
| Sex (male) | 0.644 (0.343–1.209) | 0.171 |
| IPF | 1.074 (0.476–2.423) | 0.864 |
| PaO2/FiO2 ratio | 0.998 (0.994–1.003) | 0.508 |
| SOFA score | 1.132 (0.951–1.347) | 0.162 |
| CRP | 0.949 (0.896–0.994) | 0.030 |
| LDH | 1.001 (0.999–1.003) | 0.323 |
| KL-6 | 1.000 (1.000–1.000) | 0.118 |
| Multivariate analysis | ||
| PMX-DHP therapy | 0.505 (0.270–0.904) | 0.032 |
| CRP | 0.948 (0.900–0.998) | 0.042 |
CI, confidence interval; CRP, C-reactive protein; HR, hazard ratio; IPF, idiopathic pulmonary fibrosis; KL-6, Krebs von den Lungen-6; LDH, lactate dehydrogenase; PMX-DHP, direct hemoperfusion using polymyxin B-immobilized fiber column; SOFA, Sequential Organ Failure Assessment.