Fig 1. Genome organisation of Filoviridae family members: MARV, EBOV, and RESTV.

Each box represents the open-reading frames that produce the VPs. RNA editing by addition of Us occurs on the GP transcript in order to produce GP and the ssGP. Post-translational modification of the GP protein results in two GP subunits after cleavage by host furin. Slight differences in gene overlaps and the presence of intergenic regions are evident between the different ebolavirus species, though the functional consequence of these differences is not clear at present. EBOV, Ebola virus; GP, glycoprotein; L, L-polymerase; MARV, Marburg virus; NP, nucleoprotein; RESTV, Reston virus; sGP; soluble glycoprotein; ssGP, small soluble glycoprotein; U, uridine; VP, viral protein.