Table 1. Summary of ebolavirus protein roles.

Protein	Main Role	Secondary Role
VP24	Inhibits IFN-α/β and IFN-γ signalling through interactions with importins, STAT signalling pathways, and NF-κB signalling pathways	Nucleocapsid assembly and stability RNA incorporation into VLPs Regulates transcription and translation
VP30	Initiates ebolavirus transcription	Counters RNA interference
VP35	Inhibits type-I IFN signalling by inhibiting activation of IRF-3 via dsRNA binding Inhibits type-I IFN production by upregulating SUMOylation of IRF-7 Impairs dendritic cell maturation Counters RNA interference Inhibits antiviral effects by blocking protein kinase R	Assembly of viral complex with NP and VP30 Regulates RNA synthesis by modulating NP–RNA interactions and by interacting with dynein LC8
VP40	Viral assembly and budding	Counters RNA interference Induces apoptosis in bystander lymphocytes
GP	Virus attachment and entry	Late-stage cytotoxicity in cells Decreases endothelial barrier function Directly triggers T-lymphocyte death and augments monocyte maturation
NP	Key component of ribonucleoprotein complex, encapsidates viral genome and protects viral mRNA from degradation
L	Involved in transcription and regulation of viral genome and mRNA editing

Abbreviations: dsRNA, double-stranded RNA; GP, glycoprotein; IFN, interferon; IRF, interferon regulatory factor; L, L-polymerase; LC8, light chain 8; NF-κB, nuclear factor kappa B; NP, nucleoprotein; STAT, signal transducer and activator of transcription; SUMO, small ubiquitin-like modifier; VLPs, virus-like particles; VP, viral protein