| Palbociclib |
CDK4 |
Targeting cancer stem cell propagation with palbociclib, a CDK4/6 inhibitor: Telomerase drives tumor cell heterogeneity. [42] |
| Arsenic trioxide |
CCND1 MAPK1 IKBKB |
Arsenic trioxide sensitizes cancer stem cells to chemoradiotherapy. A new approach in the treatment of inoperable glioblastoma multiforme. [49] |
| Insulin Human |
RB1 |
|
| Insulin Pork |
RB1 |
|
| Regorafenib |
MAPK11 |
|
| Acetylsalicylic acid |
TP53 IKBKB PRKAG2 PRKAG3 PRKAA1 PRKAA2 PRKAG1 PRKAB1 |
|
| Cobimetinib |
MAP2K1 |
|
| Bosutinib |
MAP2K1 MAP2K2 |
The therapeutic potential of targeting ABC transporters to combat multi-drug resistance. [43] |
| Trametinib |
MAP2K1 MAP2K2 |
Roles of EGFR and KRAS and their downstream signaling pathways in pancreatic cancer and pancreatic cancer stem cells. [44] |
| Isoprenaline |
MAPK1PIK3R1 |
|
| Celecoxib |
PDPK1 |
Expression Patterns of Cancer Stem Cell Markers During Specific Celecoxib Therapy in Multistep Rat Colon Carcinogenesis Bioassays. [45] |
| Sucralfate |
EGF |
|
| Cetuximab |
EGFR |
Antitumor activity of Cetuximab in combination with Ixabepilone on triple negative breast cancer stem cells. [50] |
| Trastuzumab |
EGFR |
Cancer stem cell-driven efficacy of trastuzumab (Herceptin): towards a reclassification of clinically HER2-positive breast carcinomas. [51] |
| Lidocaine |
EGFR |
|
| Gefitinib |
EGFR |
|
| Erlotinib |
EGFR |
Tyr1068-phosphorylated epidermal growth factor receptor (EGFR) predicts cancer stem cell targeting by erlotinib in preclinical models of wild-type EGFR lung cancer. [52] |
| Lapatinib |
EGFR |
|
| Panitumumab |
EGFR |
Cancer Stem Cell-Based Models of Colorectal Cancer Reveal Molecular Determinants of Therapy Resistance. [53] |
| Vandetanib |
EGFR |
|
| Afatinib |
EGFR |
Afatinib radiosensitizes head and neck squamous cell carcinoma cells by targeting cancer stem cells. [54] |
| Osimertinib |
EGFR |
|
| Necitumumab |
EGFR |
|
| Mesalazine |
IKBKB |
Mesalazine inhibits the β-catenin signalling pathway acting through the upregulation of μ-protocadherin gene in colo-rectal cancer cells. [55] |
| Sulfasalazine |
IKBKB |
|
| Auranofin |
IKBKB |
|
| Acetylcysteine |
IKBKB |
|
| Urea |
CTNNB1 |
|
| Lithium |
GSK3B |
|
| Cyclosporine |
PPP3R2 |
Cancer Stem Cells in Prostate Cancer: Implications for Targeted Therapy. [56] |
| Pseudoephedrine |
NFATC1 |
|
| Halothane |
GNG2 |
|
| Adenosine monophosphate |
PRKAA1 PRKAB1 |
|
| Adenosine triphosphate |
PRKAA1 |
Extracellular ATP reduces tumor sphere growth and cancer stem cell population in glioblastoma cells. [57] |
| Phenformin |
PRKAA1 |
Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells. [46] |
| Metformin |
PRKAB1 |
Metformin and prostate cancer stem cells: a novel therapeutic target. [47] |
| Sorafenib |
FLT3 |
|
| Sunitinib |
FLT3 |
|
| Ponatinib |
FLT3 |
|
| Nintedanib |
FLT3 |
|
