Fig 2. The β/α-cell ratio change pre-, post-isolation and post-transplantation.

(A)Representative photograph of islet stricture. During islet isolation and transplantation, islets are exposed to mechanical, chemical, and hypoxic-reperfusion injury, generally leading to ROS generation. (B)The change of β/α-cell ratio in pre-, post-isolation, and post-transplantation into diabetic immune-deficient mice was examined. The β/α-cell ratio significantly decreased over the procedures, indicating a higher susceptibility of β-cells to the stress factors (N = 5).