Table 2. In vitro growth inhibition of cancer cell lines by KuWal151 (8c)a.
Cell line | Cancer origin | GI50 [μM] | SPF45b [FPKM]c | CLK1 [FPKM]c |
786–0 | Renal Cancer | 0.275 | 18 | 13 |
A498 | Renal Cancer | 0.166 | 10 | 9 |
A549/ATCC | Non-Small Cell Lung Cancer | 0.389 | 16 | 11 |
ACHN | Renal Cancer | 0.372 | 15 | 6 |
BT-549 | Breast Cancer | 0.204 | n.a. | n.a. |
CCRF-CEM | Leukemia | 0.178 | n.a. | n.a. |
COLO 205 | Colon Cancer | 0.209 | n.a. | n.a. |
DU-145 | Prostate Cancer | 0.316 | 22 | 7 |
EKVX | Non-Small Cell Lung Cancer | 0.355 | 19 | 12 |
HCC-2998 | Colon Cancer | 0.912 | n.a | n.a |
HCT-116 | Colon Cancer | 0.191 | 22 | 9 |
HCT-15 | Colon Cancer | 0.178 | 25 | 15 |
HL-60(TB) | Leukemia | 0.141 | 9 | 14 |
HOP-92 | Non-Small Cell Lung Cancer | 5.62 | 19 | 7 |
HS 578T | Breast Cancer | 0.204 | 6 | 8 |
HT29 | Colon Cancer | 0.174 | 19 | 15 |
IGROV1 | Ovarian Cancer | 0.427 | 21 | 11 |
K-562 | Leukemia | 0.162 | 18 | 9 |
KM12 | Colon Cancer | 0.209 | 20 | 39 |
LOX IMVI | Melanoma | 0.245 | 17 | 17 |
M14 | Melanoma | 0.132 | n.a | n.a |
MCF7 | Breast Cancer | 0.174 | 19 | 11 |
MDA-MB-231/ATCC | Breast Cancer | 1.38 | 18 | 14 |
MDA-MB-435 | Melanoma | 0.0724 | 11 | 22 |
MDA-MB-468 | Breast Cancer | 0.234 | 20 | 11 |
MOLT-4 | Leukemia | 0.257 | n.a | n.a |
NCI/ADR-RES | Ovarian Cancer | 0.178 | n.a | n.a |
NCI-H226 | Non-Small Cell Lung Cancer | 28.8 | 8 | 6 |
NCI-H23 | Non-Small Cell Lung Cancer | 0.525 | 25 | 12 |
NCI-H322M | Non-Small Cell Lung Cancer | 2.39 | 7 | 13 |
NCI-H460 | Non-Small Cell Lung Cancer | 0.209 | 15 | 4 |
NCI-H522 | Non-Small Cell Lung Cancer | 0.158 | 9 | 15 |
OVCAR-3 | Ovarian Cancer | 0.191 | 12 | 11 |
OVCAR-4 | Ovarian Cancer | 0.912 | 15 | 9 |
OVCAR-5 | Ovarian Cancer | 1.25 | n.a | n.a |
OVCAR-8 | Ovarian Cancer | 0.724 | 36 | 10 |
PC-3 | Prostate Cancer | 0.339 | 12 | 15 |
RPMI-8226 | Leukemia | 0.288 | 19 | 10 |
RXF 393 | Renal Cancer | 0.457 | n.a | n.a |
SF-268 | CNS Cancer | 0.437 | 12 | 5 |
SF-295 | CNS Cancer | 0.224 | 11 | 8 |
SF-539 | CNS Cancer | 0.166 | 12 | 12 |
SK-MEL-2 | Melanoma | 0.316 | n.a | n.a |
SK-MEL-28 | Melanoma | 0.692 | 8 | 12 |
SK-MEL-5 | Melanoma | 0.407 | 9 | 9 |
SK-OV-3 | Ovarian Cancer | 0.275 | 20 | 9 |
SN12C | Renal Cancer | 0.331 | n.a | n.a |
SNB-19 | CNS Cancer | 0.389 | n.a | n.a |
SNB-75 | CNS Cancer | 0.151 | 10 | 11 |
SR | Leukemia | 0.151 | n.a | n.a |
SW-620 | Colon Cancer | 0.209 | 22 | 17 |
T-47D | Breast Cancer | 0.309 | 20 | 7 |
TK-10 | Renal Cancer | 10.2 | n.a | n.a |
U251 | CNS Cancer | 0.263 | n.a | n.a |
UACC-257 | Melanoma | >50.1 | 8 | 12 |
UACC-62 | Melanoma | 0.275 | 10 | 12 |
UO-31 | Renal Cancer | 0.832 | 10 | 6 |
a n.a. = not available
b synonym in Expression Atlas: RBM17
c FPKM (fragments per kilobase of exon model per million reads mapped) is a common unit of gene expression calculated from RNA-sequencing data. The calculation takes into account gene length and total number of mapped reads [46].