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. 2018 May 3;13(5):e0196787. doi: 10.1371/journal.pone.0196787

Fig 4. REV-ERBβ-deficient mice show increased muscle expression of mitochondrial and fatty acid oxidation genes compared to REV-ERBα-deficient mice.

Fig 4

(A) qRT-PCR analysis of muscle (quadriceps) from REV-ERBβ-deficient or wild-type littermate controls. Analysis includes effects on expression on RORα, REV-ERBα, and core molecular clock genes as well as genes encoding proteins involved in fatty acid oxidation, lipid metabolism, and effects on expression on muscle fiber type (Tpm3, Myh2, Myh4). (n = 7 mice per group) Data representative of 3 independent experiments demonstrating similar results. (B) qRT-PCR analysis of muscle (quadriceps) from REV-ERBα-deficient or wild-type littermate controls. Analysis includes effects on expression on RORα, REV-ERBα, and core molecular clock genes as well as on expression of genes encoding proteins involved in fatty acid oxidation, lipid metabolism, and expression on muscle fiber type (Tpm3, Myh2, Myh4). (n = 5 mice per group) Data representative of 2 independent experiments demonstrating similar results. Values are mean±s.e.m. Statistical significance was assessed using Student’s two-tailed t-tests. *p<0.05, ** p<0.01.