Fig 1. Silencing SREBP-1 in vivo reduces hepatic insulin signaling.

Mice were administered 1x10¹¹ viral particles of HD-Ad.shSREBP1 or HD-Ad.shSCR, and euthanized after 8 days under fed, 24-hour fasted or 24-hour fasted followed by a 4.5 hour refeeding period. (A) Tissue lysates were subjected to immunoblotting analysis using the antibodies shown on the left. (B) Densitometry analysis of insulin signaling molecules. Values represent mean ± SD (n = 4); *p<0.05 shSCR vs shSREBP1.