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. Author manuscript; available in PMC: 2019 Apr 26.
Published in final edited form as: J Med Chem. 2018 Apr 10;61(8):3541–3550. doi: 10.1021/acs.jmedchem.7b01804

Figure 1.

Figure 1

MPPA is efficacious against LPS induced inflammatory pain. Baseline thermal withdrawal latencies were determined for each rat before administration of compounds. After baseline determination, MPPA and the vehicle control were administered by oral gavage immediately before a 50 μl intraplantar injection of LPS in saline (arrow) to induce inflammatory pain in male rats. The efficacy of MPPA peaked at 30 min post LPS injection and was largely dissipated by 4 hours. The efficacy at 3 mg/kg was statistically significant compared to vehicle control. Scores are the mean ± SEM reported as percent of baseline (baseline scores normalized to 100%) calculated as the score *100/baseline score (Mann-Whitney Rank Sum Test, T = 448.000 n(small)= 24 n(big)= 36 *p≤0.001, n=6-9/group).