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Correlation between cholinesterase inhibition and plasma concentration of donepezil. After oral treatment, the maximal drug concentration (Cmax) was reached after approximately 2.5 ± 0.5 h and gradually decreased (A). AChE activity was inhibited by increasing plasma concentrations of donepezil (B). Plasma AChE activity levels were negatively correlated with the concentration of donepezil in the plasma (C).
