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Relationship between the brain concentration of donepezil and the pharmacological effects. Donepezil HCl (0.3–10 mg/kg free drug dissolved in saline) was administered orally for four consecutive days to the corresponding treatment groups (8 animals per group). As the concentration of donepezil in the brain increased, the recovery of spontaneous alternations (SA) also improved. Data represent the means ± SEM.
