Table 1.

Donepezil pharmacokinetic parameters after oral treatment to hairless rats (mean ± SD)

Parameter	PO (3 mg/kg)	PO (10 mg/kg)
Tmax (h)	1.2 ± 0.4	1.4 ± 0.5
Cmax (ng/ml)	17.9 ± 2.4	44.1 ± 7.9
T1/2 (h)	8.5 ± 1.9	3.4 ± 1.0
AUC0→inf (ng×h/ml)	70.9 ± 11.2	240.5 ± 31.5
BA (%)	3.6

Absolute bioavailability (BA) was calculated according to a slightly modified method described Saluja et al (2013).